Modeling TCR Signaling Complex Formation in Positive Selection

Modeling TCR Signaling Complex Formation

TCR- CDR3 Loop Audition Regulates Positive Selection

Editing autoreactive TCR enables efficient positive selection.

Allelic exclusion is inefficient at the TCRalpha locus, allowing a sizeable portion of T cells to carry two functional TCRs. The potential danger of dual TCR expression is a rescue of autoreactive TCRs during selection in the thymus and subsequent development of autoimmunity. In this study, we examine the reason(s) for replacing an autoreactive TCR and for allowing the survival of cells carryin...

Histocompatibility Complex Molecules of Expressing a Single TCR by Multiple Major Cross-Positive Selection of Thymocytes

LKB1 regulates TCR-mediated PLCγ1 activation and thymocyte positive selection.

The serine/threonine kinase LKB1 is a tumour suppressor that regulates cell growth, polarity, and proliferation in many different cell types. We previously demonstrated that LKB1 controls thymocyte survival via regulation of AMPK activation. In this study, we show that LKB1 was also involved in thymocyte positive selection through regulation of T cell receptor (TCR) signalling. Both Lck-Cre- an...